In vitro assessment of the cytotoxic effects of novel RGD analogues | Zendy

Anelia Balacheva | Zendy; Иван Илиев | Zendy; Roumyana Detcheva | Zendy; Tatyana Dzimbova | Zendy; Tamara Pajpanova | Zendy; Evgeny Golovinsky | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In vitro assessment of the cytotoxic effects of novel RGD analogues

Author(s) -

Anelia Balacheva,

Иван Илиев,

Roumyana Detcheva,

Tatyana Dzimbova,

Tamara Pajpanova,

Evgeny Golovinsky

Publication year - 2012

Publication title -

biodiscovery

Language(s) - English

Resource type - Journals

ISSN - 2050-2966

DOI - 10.7750/biodiscovery.2012.4.1

Subject(s) - cytotoxic t cell , extracellular matrix , in vitro , intracellular , chemistry , cell adhesion , cytotoxicity , apoptosis , cell culture , cell , adhesion , extracellular , microbiology and biotechnology , biochemistry , cancer research , biology , genetics , organic chemistry

The RGD sequence is present in many extracellular matrix proteins and intracellular proteins, including caspases. Synthetic RGD peptides may affect adhesion, migration and tumour metastasis, or directly induce apoptosis. Several RGD peptides were synthesized, and their anti-adhesive and cytotoxic properties were analyzed in vitro. Here we present the cytotoxic activities of RGD, R(NO2)GD, CavGD and RGD-OMe on non-tumour 3T3 cells and tumour cell lines HepG2 and MCF-7. The cell growth inhibitory effects of RGD-OMe are significantly higher than those of RGD on the cell lines used. Evidently the modification in the carboxylic group of RGD with simple esterification increases the cell growth inhibitory effects of the parent compound

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research