Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis | Zendy

Che Othman Siti Sarah | Zendy; Norasnieda Md Shukri | Zendy; Noor Suryani Mohd Ashari | Zendy; Kah Keng Wong | Zendy

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Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis

Author(s) -

Che Othman Siti Sarah,

Norasnieda Md Shukri,

Noor Suryani Mohd Ashari,

Kah Keng Wong

Publication year - 2020

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.9834

Subject(s) - tight junction , hdac1 , immunology , proinflammatory cytokine , histone deacetylase 2 , mucous membrane of nose , population , medicine , nasal administration , microbiology and biotechnology , biology , histone , cancer research , inflammation , histone deacetylase , genetics , gene , environmental health

Allergic rhinitis (AR) is a common disease affecting 400 million of the population worldwide. Nasal epithelial cells form a barrier against the invasion of environmental pathogens. These nasal epithelial cells are connected together by tight junction (TJ) proteins including zonula occludens-1 (ZO-1), ZO-2 and ZO-3. Impairment of ZO proteins are observed in AR patients whereby dysfunction of ZOs allows allergens to pass the nasal passage into the subepithelium causing AR development. In this review, we discuss ZO proteins and their impairment leading to AR, regulation of their expression by Th1 cytokines (i.e., IL-2, TNF- α and IFN- γ ), Th2 cytokines (i.e., IL-4 and IL-13) and histone deacetylases (i.e., HDAC1 and HDAC2). These findings are pivotal for future development of targeted therapies by restoring ZO protein expression and improving nasal epithelial barrier integrity in AR patients.

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