The antifungal activity of vapour phase of odourless thymol derivate | Zendy

Róbert Kubinec | Zendy; Jaroslav Blaško | Zendy; Paulína Galbavá | Zendy; Helena Jurdáková | Zendy; Jana Sádecká | Zendy; Domenico Pangallo | Zendy; Mária Bučková | Zendy; Andrea Puškárová | Zendy

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The antifungal activity of vapour phase of odourless thymol derivate

Author(s) -

Róbert Kubinec,

Jaroslav Blaško,

Paulína Galbavá,

Helena Jurdáková,

Jana Sádecká,

Domenico Pangallo,

Mária Bučková,

Andrea Puškárová

Publication year - 2020

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.9601

Subject(s) - thymol , vapours , chemistry , fungicide , antifungal , ether , food science , organic chemistry , microbiology and biotechnology , essential oil , botany , biology , neuroscience

Thymol is a substance with a great therapeutic potential possessing antibacterial and antifungal activity, with a characteristic odour that remains long after application but is not pleasant at higher concentrations. In this study, attention has been focused on describing the chemical and biological properties of the simply prepared trimethylsilyl ether of thymol (kubicin). Interestingly, kubicin has similar volatility as thymol, undergoes hydrolysis in the water (moisture; forming thymol and trimethylsilanol) and can be used at 6,000 times higher concentration than thymol without any negative and irritating odour. Kubicin showed diverse fungistatic and fungicidal activities when tested by direct contact assay, or in vapour phase. The volatile vapour of kubicin was effective on all tested fungal strains. These results suggest that vapours of kubicin might provide an alternative way to fight against fungal contamination.

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