English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The link between the gut microbiota and metabolic syndrome (MetS) has attracted widespread attention.  Christensenellaceae  was recently described as an important player in human health, while its distribution and relationship with MetS in Chinese population is still unknown. This study sought to observe the association between  Christensenellaceae  and metabolic indexes in a large sample of residents in South China. A total of 4,781 people from the GGMP project were included, and the fecal microbiota composition of these individuals was characterized by 16S rRNA sequencing and analyzed the relation between  Christensenellaceae  and metabolism using QIIME (Quantitative Insight Into Microbial Ecology, Version 1.9.1). The results demonstrated that microbial richness and diversity were increased in the group with a high abundance of  Christensenellaceae , who showed a greater complexity of the co-occurrence network with other bacteria than residents who lacked  Christensenellaceae . The enriched bacterial taxa were predominantly represented by  Oscillospira ,  Ruminococcaceae ,  RF39 ,  Rikenellaceae  and  Akkermansia  as the  Christensenellaceae  abundance increased, while the abundances of  Veillonella ,  Fusobacterium  and  Klebsiella  were significantly reduced. Furthermore,  Christensenellaceae  was negatively correlated with the pathological features of MetS, such as obesity, hypertriglyceridemia and body mass index (BMI). We found reduced levels of lipid biosynthesis and energy metabolism pathways in people with a high abundance of  Christensenellaceae , which may explain the negative relationship between body weight and  Christensenellaceae . In conclusion, we found a negative correlation between  Christensenellaceae  and MetS in a large Chinese population and reported the geographical distribution of  Christensenellaceae  in the GGMP study. The association data from this population-level research support the investigation of strains within  Christensenellaceae  as potentially beneficial gut microbes.

Regional distribution of Christensenellaceae and its associations with metabolic syndrome based on a population-level analysis