Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer | Zendy

Xin Wen | Zendy; Shui Liu | Zendy; Jiyao Sheng | Zendy; Manhua Cui | Zendy

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Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer

Author(s) -

Xin Wen,

Shui Liu,

Jiyao Sheng,

Manhua Cui

Publication year - 2020

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.9234

Subject(s) - cervical cancer , cisplatin , biology , long non coding rna , resistance (ecology) , computational biology , cancer , bioinformatics , medicine , genetics , rna , gene , ecology , chemotherapy

Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin ( cis -diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.

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