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Purpose  To investigate the association between insulin-like growth factor 1 ( IGF1 ) single-nucleotide polymorphisms (SNPs) and myopia in a young Chinese population.    Methods  A total of 654 Chinese children aged 6–13 years from one primary school participated in our study and underwent a series of comprehensive ocular examinations, including cycloplegic refraction and measurements of axial length. Myopia was defined as a spherical equivalence (SE) ≤ −0.5 D in the worse eye. In total, six tagging SNPs of  IGF1  were genotyped using the PCR-LDR (Polymerase Chain Reaction-Ligation Detection Reaction) method. We tested four different genetic modes (the allele, dominant, recessive, and additive models) of these SNPs and used multivariate logistic regression to calculate the effect of SNPs on myopia. In addition, we conducted a haplotype analysis with a variable-sized slide-window strategy.    Results  Overall, 281 myopic children and 373 non-myopic controls were included in the analysis. The SNP  rs2162679  showed a statistical difference between the two groups in both the allele ( p  = 0.0474) and additive ( p  = 0.0497) models. After adjusting for age and gender, children with the genotype AA in the SNP  rs2162679  had a higher risk of myopia than those with the genotype GG (OR = 2.219, 95% CI [1.218–4.039],  p  = 0.009). All haplotypes that varied significantly between the two groups contained the SNP  rs2162679 , and the four-SNP window  rs5742653 – rs2162679  had the lowest  p  value (Chi square = 5.768,  p  = 0.0163). However, after permutation tests, none of the associations remained statistically significant.    Conclusion  The SNP  rs2162679  in  IGF1  was associated with myopia in a young Chinese population. The G allele in the SNP  rs2162679  may protect against myopia.

Association of IGF1 single-nucleotide polymorphisms with myopia in Chinese children