English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Cynomolgus macaques ( Macaca fascicularis ,  Mafa ) have been used as important experimental animal models for carrying out biomedical researches. The results of biomedical experiments strongly depend on the immunogenetic background of animals, especially on the diversity of major histocompatibility complex (MHC) alleles. However, there is much less information available on the polymorphism of MHC class I genes in cynomolgus macaques, than is currently available for humans. In this study, we have identified 40  Mafa-A  and 60  Mafa-B  exons 2 and 3 sequences from 30 unrelated cynomolgus macaques of Vietnamese origin. Among these alleles, 28 are novel. As for the remaining 72 known alleles, 15 alleles are shared with other cynomolgus macaque populations and 32 are identical to alleles previously reported in other macaque species. A potential recombination event was observed between  Mafa-A1*091:02  and  Mafa-A1*057:01 . In addition, the  Mafa-A1  genes were found to be more diverse than human  HLA-A  and the functional residues for peptide binding sites (PBS) or TCR binding sites (TBS) in  Mafa-A1  have greater variability than that for non-PBS or non-TBS regions. Overall, this study provides important information on the diversity of  Mafa-A  and  Mafa-B  alleles from Vietnamese origin, which may help researchers to choose the most appropriate animals for their studies.

MHC class I allele diversity in cynomolgus macaques of Vietnamese origin