Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China | Zendy

Jiankui Liu | Zendy; Chunhua Wei | Zendy; Zhifeng Lin | Zendy; Wei Xia | Zendy; Ying Ma | Zendy; Ailing Dai | Zendy; Xiaoyan Yang | Zendy

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Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China

Author(s) -

Jiankui Liu,

Chunhua Wei,

Zhifeng Lin,

Wei Xia,

Ying Ma,

Ailing Dai,

Xiaoyan Yang

Publication year - 2019

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.7859

Subject(s) - biology , phylogenetic tree , genotype , virology , strain (injury) , whole genome sequencing , genetics , restriction fragment length polymorphism , genome , china , molecular epidemiology , sequence analysis , gene , political science , law , anatomy

PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 1-7-4. Additionally, FJ0908 had a 100 aa deletion (aa329–428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China.

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