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Background  Aurora kinase B ( AURKB ) is an important carcinogenic factor in various tumors, while its role in clear cell renal cell carcinoma (ccRCC) still remains unclear. This study aimed to investigate its prognostic value and mechanism of action in ccRCC.    Methods  Gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database. R software was utilized to analyze the expression and prognostic role of  AURKB  in ccRCC. Gene set enrichment analysis (GSEA) was used to analyze  AURKB  related signaling pathways in ccRCC.    Results   AURKB  was expressed at higher levels in ccRCC tissues than normal kidney tissues. Increased  AURKB  expression in ccRCC correlated with high histological grade, pathological stage, T stage, N stage and distant metastasis (M stage). Kaplan-Meier survival analysis suggested that high  AURKB  expression patients had a worse prognosis than patients with low  AURKB  expression levels. Multivariate Cox analysis showed that  AURKB  expression is a prognostic factor of ccRCC. GSEA indicated that genes involved in autoimmune thyroid disease, intestinal immune network for IgA production, antigen processing and presentation, cytokine-cytokine receptor interaction, asthma, etc., were differentially enriched in the  AURKB  high expression phenotype.    Conclusions   AURKB  is a promising biomarker for predicting prognosis of ccRCC patients and a potential therapeutic target. In addition,  AURKB  might regulate progression of ccRCC through modulating intestinal immune network for IgA production and cytokine-cytokine receptor interaction, etc. signaling pathways. However, more research is necessary to validate the findings.

AURKB: a promising biomarker in clear cell renal cell carcinoma