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Background  Rise in the number of healthcare associated or hospital acquired infections is a major problem affecting the global healthcare sector. We evaluated superior antibacterial and antibiofilm photodynamic therapy (aPDT) using malachite green encapsulated mesoporous silica nanoparticles (MG-MSN) against  Staphylococcus aureus  and  Escherichia coli , which are known to be major causative agents of nosocomial infections.    Methods  Malachite green (MG) was encapsulated on mesoporous silica nanoparticles (MSN). Fourier-transform infrared spectroscopy, Transmission electron microscopy, and spectroscopic analysis were performed to characterize the MG-MSN. The antimicrobial efficacies of MSN, MG, and MG-MSN were investigated and the results were recorded.    Results  MG-MSN was effective against both the tested bacteria.  S. aureus  was more phototoxic to MG-MSN compared to  E. coli . The antibiofilm efficacy of MG-MSN on  E. coli  and  S. aureus  was also studied. Biofilm inhibition was 65.68 ± 2.62% in  E. coli  and 79.66 ± 3.82% in  S. aureus . Cell viability assay, exopolysaccharides quantification, and confocal laser scanning microscopy studies also revealed the enhanced antibiofilm activity of MG-MSN when used as a potential photosensitizer for aPDT. This study can be extended to eradicate these strains from localized superficial infections and medical appliances, preventing nosocomial infections.

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Antimicrobial photodynamic therapy on Staphylococcus aureus and Escherichia coli using malachite green encapsulated mesoporous silica nanoparticles: an in vitro study