Loss ofwwoxexpression in zebrafish embryos causes edema and alters Ca2+dynamics | Zendy

Yusuke Tsuruwaka | Zendy; MASATAKA KONISHI | Zendy; Eriko Shimada | Zendy

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Loss ofwwoxexpression in zebrafish embryos causes edema and alters Ca²⁺dynamics

Author(s) -

Yusuke Tsuruwaka,

MASATAKA KONISHI,

Eriko Shimada

Publication year - 2015

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.727

Subject(s) - wwox , zebrafish , gene knockdown , embryo , cancer research , microbiology and biotechnology , biology , intracellular , gene , genetics , suppressor

We investigated the role of the WW domain-containing oxidoreductase ( wwox ) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca 2+ dynamics because Ca 2+ is an important intracellular messenger. Comparisons between zebrafish wwox and human WWOX sequences identified highly conserved domain structures. wwox was expressed in developing heart tissues in the zebrafish embryo. Moreover, wwox knockdown induced pericardial edema with similarities to conditions observed in human breast cancer. The wwox knockdown embryos with the edema died within a week. High Ca 2+ levels were observed at the boundary between the edema and yolk in wwox knockdown embryos.

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