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We investigated the role of the WW domain-containing oxidoreductase ( wwox ) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca 2+  dynamics because Ca 2+  is an important intracellular messenger. Comparisons between zebrafish  wwox  and human  WWOX  sequences identified highly conserved domain structures.  wwox  was expressed in developing heart tissues in the zebrafish embryo. Moreover,  wwox  knockdown induced pericardial edema with similarities to conditions observed in human breast cancer. The  wwox  knockdown embryos with the edema died within a week. High Ca 2+  levels were observed at the boundary between the edema and yolk in  wwox  knockdown embryos.

Loss ofwwoxexpression in zebrafish embryos causes edema and alters Ca2+dynamics

Loss ofwwoxexpression in zebrafish embryos causes edema and alters Ca²⁺dynamics