Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat | Zendy

Yifan He | Zendy; Wenguo Fan | Zendy; Yue Xu | Zendy; Yong liang Liu | Zendy; Hongwen He | Zendy; Fang Huang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat

Author(s) -

Yifan He,

Wenguo Fan,

Yue Xu,

Yong liang Liu,

Hongwen He,

Fang Huang

Publication year - 2019

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.6877

Subject(s) - colocalization , trigeminal ganglion , nicotinamide adenine dinucleotide phosphate , nadph dehydrogenase , melatonin , nucleus , chemistry , melatonin receptor , spinal trigeminal nucleus , medicine , receptor , sensory system , anatomy , endocrinology , biology , nitric oxide , neuroscience , nitric oxide synthase , biochemistry , enzyme , nociception , oxidase test

Melatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) in the spinal trigeminal nucleus (STN), the trigeminal ganglion (TG), and the mesencephalic trigeminal nucleus (MTN) in the rat, using histochemistry and immunohistochemistry. Our results show that MT1-positive neurons are widely distributed in the TG and the subnucleus caudalis of the STN. Furthermore, we found that MT1 colocalizes with NADPH-d throughout the TG and MTN, most extensively in the TG. The distribution pattern of MT1 and its colocalization with NADPH-d indicate that melatonin might play an important role in the trigeminal sensory system, which could be responsible for the regulation of NO levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research