Effects of deuterium oxide on cell growth and vesicle speed in RBL-2H3 cells | Zendy

Roshni Kalkur | Zendy; Andrew Ballast | Zendy; Ashley R Triplett | Zendy; Kathrin Spendier | Zendy

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Effects of deuterium oxide on cell growth and vesicle speed in RBL-2H3 cells

Author(s) -

Roshni Kalkur,

Andrew Ballast,

Ashley R Triplett,

Kathrin Spendier

Publication year - 2014

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.553

Subject(s) - deuterium , vesicle , chemistry , cell culture , microtubule , oxide , vesicular transport protein , biophysics , microbiology and biotechnology , biochemistry , biology , physics , membrane , organic chemistry , quantum mechanics , genetics

For the first time we show the effects of deuterium oxide on cell growth and vesicle transport in rat basophilic leukemia (RBL-2H3) cells. RBL-2H3 cells cultured with 15 moles/L deuterium showed decreased cell growth which was attributed to cells not doubling their DNA content. Experimental observations also showed an increase in vesicle speed for cells cultured in deuterium oxide. This increase in vesicle speed was not observed in deuterium oxide cultures treated with a microtubule-destabilizing drug, suggesting that deuterium oxide affects microtubule-dependent vesicle transport.

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