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Rice  koji  is considered a readily accessible functional food that may have health-promoting effects. We investigated whether white, yellow, and red  koji  have the anti-obesity effect in C57BL/6J mice fed a high-fat diet (HFD), which is a model for obesity. Mice were fed HFD containing 10% (w/w) of rice  koji  powder or steamed rice for 4 weeks. Weight gain, epididymal white adipose tissue, and total adipose tissue weight were significantly lower in all rice  koji  groups than in the HFD-rice group after 4 weeks. Feed efficiency was significantly reduced in the yellow  koji  group. Blood glucose levels were significantly lower in the white and red  koji  groups with HOMA-R and leptin levels being reduced in the white  koji  group. White and red  koji  increased glucose uptake and GLUT4 protein expression in L6 myotube cells. These results showed that all rice  koji  have the anti-obesity or anti-diabetes effects although the mechanisms may differ depending on the type of rice  koji  consumed.

Ricekojireduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice