The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases | Zendy

Marcin Gradowski | Zendy; Krzysztof Pawłowski | Zendy

Open Access

The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Author(s) -

Marcin Gradowski,

Krzysztof Pawłowski

Publication year - 2017

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.3849

Subject(s) - effector , legionella pneumophila , proteases , serine , serine protease , biology , microbiology and biotechnology , protease , biochemistry , enzyme , bacteria , genetics , phosphorylation

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

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