Ficus septicaplant extracts for treating Dengue virusin vitro | Zendy

Nan-Chieh Huang | Zendy; Wan-Ting Hung | Zendy; Wei-Lun Tsai | Zendy; Feng-Yi Lai | Zendy; You-Sheng Lin | Zendy; Mei-Shu Huang | Zendy; JihJung Chen | Zendy; Wei-Yu Lin | Zendy; Jing-Ru Weng | Zendy; Tsung-Hsien Chang | Zendy

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Ficus septicaplant extracts for treating Dengue virusin vitro

Author(s) -

Nan-Chieh Huang,

Wan-Ting Hung,

Wei-Lun Tsai,

Feng-Yi Lai,

You-Sheng Lin,

Mei-Shu Huang,

JihJung Chen,

Wei-Yu Lin,

Jing-Ru Weng,

Tsung-Hsien Chang

Publication year - 2017

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.3448

Subject(s) - dengue virus , dengue fever , virology , virus , biology , microbiology and biotechnology , medicinal plants , traditional medicine , flavivirus , in vitro , medicine , botany , biochemistry

Dengue virus types 1-4 (DENV-1-4) are positive-strand RNA viruses with an envelope that belongs to the Flaviviridae . DENV infection threatens human health worldwide. However, other than supportive treatments, no specific therapy is available for the infection. In order to discover novel medicine against DENV, we tested 59 crude extracts, without cytotoxicity, from 23 plants in vitro ; immunofluorescence assay revealed that the methanol extracts of fruit, heartwood, leaves and stem from Ficus septica Burm. f. had a promising anti-DENV-1 and DENV-2 effect. However, infection with the non-envelope picornavirus , Aichi virus, was not inhibited by treatment with F. septica extracts. F. septica may be a candidate antiviral drug against an enveloped virus such as DENV.

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