Comparative proteomics ofRhizopus delemarATCC 20344 unravels the role of amino acid catabolism in fumarate accumulation | Zendy

Dorett I. Odoni | Zendy; Juan Antonio TamayoRamos | Zendy; Jasper Sloothaak | Zendy; Ruben Heck | Zendy; Vítor A. P. Martins dos Santos | Zendy; Leo H. de Graaff | Zendy; María SuárezDiez | Zendy; Peter J. Schaap | Zendy

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Comparative proteomics ofRhizopus delemarATCC 20344 unravels the role of amino acid catabolism in fumarate accumulation

Author(s) -

Dorett I. Odoni,

Juan Antonio TamayoRamos,

Jasper Sloothaak,

Ruben Heck,

Vítor A. P. Martins dos Santos,

Leo H. de Graaff,

María SuárezDiez,

Peter J. Schaap

Publication year - 2017

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.3133

Subject(s) - catabolism , fumarate reductase , biochemistry , proteomics , chemistry , metabolic pathway , citric acid cycle , metabolism , biology , enzyme , gene , succinate dehydrogenase

The filamentous fungus Rhizopus delemar naturally accumulates relatively high amounts of fumarate. Although the culture conditions that increase fumarate yields are well established, the network underlying the accumulation of fumarate is not yet fully understood. We set out to increase the knowledge about fumarate accumulation in R. delemar . To this end, we combined a transcriptomics and proteomics approach to identify key metabolic pathways involved in fumarate production in R. delemar , and propose that a substantial part of the fumarate accumulated in R. delemar during nitrogen starvation results from the urea cycle due to amino acid catabolism.

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