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Much is known regarding the antibiotic susceptibility of planktonic cultures of  Mycobacterium tuberculosis , the bacterium responsible for the lung disease tuberculosis (TB). As planktonically-grown  M. tuberculosis  are unlikely to be entirely representative of the bacterium during infection, we set out to determine how effective a range of anti-mycobacterial treatments were against  M. tuberculosis  growing as a biofilm, a bacterial phenotype known to be more resistant to antibiotic treatment. Light levels from bioluminescently-labelled  M. tuberculosis  H37Rv (strain BSG001) were used as a surrogate for bacterial viability, and were monitored before and after one week of treatment. After treatment, biofilms were disrupted, washed and inoculated into fresh broth and plated onto solid media to rescue any surviving bacteria. We found that in this phenotypic state  M. tuberculosis  was resistant to the majority of the compounds tested. Minimum inhibitory concentrations (MICs) increased by 20-fold to greater than 1,000-fold, underlying the potential of this phenotype to cause significant problems during treatment.

Effect of common and experimental anti-tuberculosis treatments onMycobacterium tuberculosisgrowing as biofilms