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Background   Daldinia eschscholtzii  is a filamentous wood-inhabiting endophyte commonly found in woody plants. Here, we report the identification and characterization of nine  D. eschscholtzii  isolates from skin scrapings, nail clippings, and blood.    Methods  The nine isolates were identified based on colony morphology, light microscopy, and internal transcribed spacer (ITS)-based phylogeny.  In vitro  antifungal susceptibility of the fungal isolates was evaluated by the Etest to determine the minimum inhibitory concentration (MIC).    Results  The nine isolates examined were confirmed as  D. eschscholtzii . They exhibited typical features of  Daldinia  sp. on Sabouraud Dextrose Agar, with white felty colonies and black-gray coloration on the reverse side. Septate hyphae, branching conidiophore with conidiogenous cells budding from its terminus, and nodulisporium-like conidiophores were observed under the microscope. Phylogenetic analysis revealed that the nine isolates were clustered within the  D. eschscholtzii  species complex. All the isolates exhibited low MICs against azole agents (voriconazole, posaconazole, itraconazole, and ketoconazole), as well as amphotericin B, with MIC of less than 1 µg/ml.    Discussion  Early and definitive identification of  D. eschscholtzii  is vital to reducing misuse of antimicrobial agents. Detailed morphological and molecular characterization as well as antifungal profiling of  D. eschscholtzii  provide the basis for future studies on its biology, pathogenicity, and medicinal potential.

Identification and characterization ofDaldinia eschscholtziiisolated from skin scrapings, nails, and blood