Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies | Zendy

Phillip Lord | Zendy; Rachel Spiering | Zendy; Juan Carlos Aguillón | Zendy; Amy E. Anderson | Zendy; Silke Appel | Zendy; Daniel BenítezRibas | Zendy; Anja ten Brinke | Zendy; Femke Broere | Zendy; Nathalie Cools | Zendy; María Cristina Cuturi | Zendy; Julie Diboll | Zendy; Edward K. Geissler | Zendy; Nick Giannoukakis | Zendy; Silvia Gregori | Zendy; S. Marieke van Ham | Zendy; Staci Lattimer | Zendy; Lindsay J. Marshall | Zendy; Rachel A. Harry | Zendy; James A. Hutchinson | Zendy; John D. Isaacs | Zendy; Irma Joosten | Zendy; Cees van Kooten | Zendy; Ascensión López Dı́az de Cerio | Zendy; Tatjaikolić | Zendy; Haluk Barbaros Oral | Zendy; Ljiljana SofronićMilosavljević | Zendy; Thomas Ritter | Zendy; Paloma Riquelme | Zendy; Angus W. Thomson | Zendy; Massimo Trucco | Zendy; Marta VivesPi | Zendy; Eva MartínezCáceres | Zendy; Catharien M. U. Hilkens | Zendy

Open Access

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

Author(s) -

Phillip Lord,

Rachel Spiering,

Juan Carlos Aguillón,

Amy E. Anderson,

Silke Appel,

Daniel BenítezRibas,

Anja ten Brinke,

Femke Broere,

Nathalie Cools,

María Cristina Cuturi,

Julie Diboll,

Edward K. Geissler,

Nick Giannoukakis,

Silvia Gregori,

S. Marieke van Ham,

Staci Lattimer,

Lindsay J. Marshall,

Rachel A. Harry,

James A. Hutchinson,

John D. Isaacs,

Irma Joosten,

Cees van Kooten,

Ascensión López Dı́az de Cerio,

Tatjaikolić,

Haluk Barbaros Oral,

Ljiljana SofronićMilosavljević,

Thomas Ritter,

Paloma Riquelme,

Angus W. Thomson,

Massimo Trucco,

Marta VivesPi,

Eva MartínezCáceres,

Catharien M. U. Hilkens

Publication year - 2016

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.2300

Subject(s) - transplantation , computer science , medicine , immunology , computational biology , biology , surgery

Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.

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