Open AccessAssociation between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics
Author(s) -
José Rico-Gomis,
Antonio PalazónBru,
Irene Triano-García,
Luis Fabián Mahecha-García,
Ana GarcíaMonsalve,
Andrés NavarroRuiz,
Berta Villagordo-Peñalver,
Jessica Jiménez-Abril,
Alicia Martínez-Hortelano,
Vicente Gil-Guillén
Publication year - 2016
Publication title -
peerj
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.927
H-Index - 70
ISSN - 2167-8359
DOI - 10.7717/peerj.2163
Subject(s) - metabolic syndrome , allele , logistic regression , medicine , polymorphism (computer science) , association (psychology) , gene polymorphism , genetics , bioinformatics , gene , biology , psychology , obesity , psychotherapist
Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.
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