The impact of serum uric acid on the natural history of glomerular filtration rate: a retrospective study in the general population | Zendy

Ying Xu | Zendy; Xiang Liu | Zendy; Xiaohe Sun | Zendy; Yibing Wang | Zendy

Open Access

The impact of serum uric acid on the natural history of glomerular filtration rate: a retrospective study in the general population

Author(s) -

Ying Xu,

Xiang Liu,

Xiaohe Sun,

Yibing Wang

Publication year - 2016

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.1859

Subject(s) - renal function , kidney disease , natural history , context (archaeology) , medicine , uric acid , population , retrospective cohort study , demography , endocrinology , biology , environmental health , paleontology , sociology

Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the association of the SUA level with the GFR decline in a general population. Two thousand, seven hundred and eighty-nine subjects who visited the Health Checkup Clinic both at 2008 and 2013 were identified. A significant inverse correlation was observed between change in SUA from 2008–2013 ( Δ SUA) and change in eGFR (ΔeGFR) during the same period. Multivariate regression analysis of ΔeGFR indicated that the increase in SUA over time were a negative predictor of the change in eGFR. Our result indicates that the decline of eGFR over years is larger in subjects with an increased SUA level, which helps to underline the importance of SUA level management in the context of kidney function preservation.

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