SUMOylation inTrypanosoma brucei | Zendy

Cornelia Klein | Zendy; Dorothea Droll | Zendy; Christine Clayton | Zendy

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SUMOylation inTrypanosoma brucei

Author(s) -

Cornelia Klein,

Dorothea Droll,

Christine Clayton

Publication year - 2013

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.180

Subject(s) - sumo protein , trypanosoma brucei , sumo enzymes , protease , biology , ubiquitin , microbiology and biotechnology , trypanosoma , enzyme , biochemistry , genetics , gene

Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO ( Tb 927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 ( Tb 927.2.2460) and the SUMO-specific protease SENP ( Tb 927.9.2220) are involved in SUMOylation and SUMO removal, respectively.

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