Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2subunit of GABAAreceptors? | Zendy

Roland Baur | Zendy; Jürg Gertsch | Zendy; Erwin Sigel | Zendy

Open Access

Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β₂subunit of GABA_Areceptors?

Author(s) -

Roland Baur,

Jürg Gertsch,

Erwin Sigel

Publication year - 2013

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.149

Subject(s) - gpr18 , glycine receptor , glycine , gabaa receptor , endocannabinoid system , cannabinoid receptor , receptor , chemistry , anandamide , cannabinoid , class c gpcr , gabaa rho receptor , biochemistry , biophysics , agonist , amino acid , biology , metabotropic receptor

NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α 1 β 2 γ 2 GABA A receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.

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