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Cedecea neteri  is a very rare human pathogen. We have isolated a strain of  C. neteri  SSMD04 from pickled mackerel sashimi identified using molecular and phenotypics approaches. Using the biosensor  Chromobacterium violaceum  CV026, we have demonstrated the presence of short chain  N -acyl-homoserine lactone (AHL) type quorum sensing (QS) activity in  C. neteri  SSMD04. Triple quadrupole LC/MS analysis revealed that  C. neteri  SSMD04 produced short chain  N -butyryl-homoserine lactone (C4-HSL). With the available genome information of  C. neteri  SSMD04, we went on to analyse and identified a pair of  luxI/R  homologues in this genome that share the highest similarity with  croI/R  homologues from  Citrobacter rodentium . The AHL synthase, which we named  cneI (636 bp), was found in the genome sequences of  C. neteri  SSMD04. At a distance of 8bp from  cneI  is a sequence encoding a hypothetical protein, potentially the cognate receptor, a  luxR  homologue which we named it as  cneR . Analysis of this protein amino acid sequence reveals two signature domains, the autoinducer-binding domain and the C-terminal effector which is typical characteristic of  luxR . In addition, we found that this genome harboured an orphan  luxR  that is most closely related to  easR  in  Enterobacter asburiae . To our knowledge, this is the first report on the AHL production activity in  C. neteri , and the discovery of its  luxI / R  homologues, the orphan receptor and its whole genome sequence.

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Genome analysis of quorum sensingCedecea neteriSSMD04 leads to identification of its novel signaling synthase (cneI), cognate receptor (cneR) and an orphan receptor