210Po microsphere radiological design for tumor vascular disruption | Zendy

JJ Bevelacqua | Zendy

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²¹⁰Po microsphere radiological design for tumor vascular disruption

Author(s) -

JJ Bevelacqua

Publication year - 2015

Publication title -

peerj

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.927

H-Index - 70

ISSN - 2167-8359

DOI - 10.7717/peerj.1143

Subject(s) - microsphere , arteriole , vascular wall , nuclear medicine , biomedical engineering , medicine , chemistry , materials science , radiology , microcirculation , chemical engineering , engineering

The feasibility of disrupting a tumor’s vascular structure using 210 Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for 210 Po alpha particles are sufficient to disrupt a tumor’s arteriole structure while minimizing the dose outside the blood vessel wall. 210 Po photons contribute minimal dose to healthy tissue. The requisite activity of 210 Po to facilitate vascular disruption is calculated.

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