Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats | Zendy

Guo Haiyu | Zendy; Ban Young-Hwan | Zendy; Cha Yeseul | Zendy; Taesu Kim | Zendy; Lee Sung-Pyo | Zendy; Suk Eun | Zendy; Ji-Eun Choi | Zendy; Woom Da | Zendy; Yon Jung-Min | Zendy; Choi Ehn-Kyoung | Zendy; Kim Yun-Bae | Zendy

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Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats

Author(s) -

Guo Haiyu,

Ban Young-Hwan,

Cha Yeseul,

Taesu Kim,

Lee Sung-Pyo,

Suk Eun,

Ji-Eun Choi,

Woom Da,

Yon Jung-Min,

Choi Ehn-Kyoung,

Kim Yun-Bae

Publication year - 2017

Publication title -

journal of biomedical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 31

eISSN - 2352-4685

pISSN - 1674-8301

DOI - 10.7555/jbr.31.20160095

Subject(s) - perilla , blood lipids , medicine , stroke (engine) , chemistry , cholesterol , raw material , mechanical engineering , organic chemistry , engineering

Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases, the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated. Sprague-Dawley rats were fed a diet containing the oils or trans-fat, and then body weights, blood lipids, and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion (MCAO) were analyzed. All the oils and trans-fat, except perilla oil, significantly increased body fats and body weight gain. Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides, respectively, while perilla oil decreased both cholesterols and triglycerides. Perilla oil not only attenuated cerebral infarction, but also restored locomotor activity and rota-rod performances of MCAO rats. It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.

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