Open AccessAssociation of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Author(s) -
Hu Xu,
Jiang Linfei,
Tang Chenhui,
Ju Yuehong,
Jiu Li,
Yongyue Wei,
Li Guo,
Yang Zhao
Publication year - 2017
Publication title -
journal of biomedical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 31
eISSN - 2352-4685
pISSN - 1674-8301
DOI - 10.7555/jbr.31.20160087
Subject(s) - single nucleotide polymorphism , meta analysis , breast cancer , oncology , medicine , association (psychology) , genetics , biology , cancer , genotype , gene , psychology , psychotherapist
Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants ofESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA+ GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms ofESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.
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