PCSK9 and triglyceride-rich lipoprotein metabolism | Zendy

Druce Irena | Zendy; Abujrad Hussein | Zendy; Chye Teik | Zendy

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PCSK9 and triglyceride-rich lipoprotein metabolism

Author(s) -

Druce Irena,

Abujrad Hussein,

Chye Teik

Publication year - 2015

Publication title -

journal of biomedical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 31

eISSN - 2352-4685

pISSN - 1674-8301

DOI - 10.7555/jbr.29.20150052

Subject(s) - pcsk9 , endocrinology , medicine , triglyceride , kexin , ldl receptor , lipoprotein , apolipoprotein b , postprandial , lipid metabolism , proprotein convertase , chemistry , biology , cholesterol , insulin

Pro-protein convertase subtilisin-kexin 9 (PCSK9) is known to affect low-density lipoprotein (LDL) metabolism, but there are indications from several lines of research that it may also influence the metabolism of other lipoproteins, especially triglyceride-rich lipoproteins (TRL). This review summarizes the current data on this possible role of PCSK9. A link between PCSK9 and TRL has been suggested through the demonstration of (1) a correlation between plasma PCSK9 and triglyceride (TG) levels in health and disease, (2) a correlation between plasma PCSK9 and markers of carbohydrate metabolism, which is closely related to TG metabolism, (3) an effect of TG-lowering fibrate therapy on plasma PCSK9 levels, (4) an effect of PCSK9 on postprandial lipemia, (5) an effect of PCSK9 on adipose tissue biology, (6) an effect of PCSK9 on apolipoprotein B production from the liver and intestines, (7) an effect of PCSK9 on receptors other than low density lipoprotein receptor (LDLR) that are involved in TRL metabolism, and (8) an effect of anti-PCSK9 therapy on serum TG levels. The underlying mechanisms are unclear but starting to emerge.

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