A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population | Zendy

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A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population

Author(s) -

Yao Liu

Publication year - 2012

Publication title -

journal of biomedical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.617

H-Index - 31

eISSN - 2352-4685

pISSN - 1674-8301

DOI - 10.7555/jbr.26.20110087

Subject(s) - odds ratio , germline , medicine , cancer , genotype , carcinogenesis , oncology , confidence interval , missense mutation , gastroenterology , exon , germline mutation , logistic regression , endocrinology , biology , genetics , gene , mutation

MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF), play a pivotal role in the activties of tumor cells. A germline missense variant in exon 2 of the MET gene, N375S (rs33917957 A>G), may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis. In this study, we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls. Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and gastric cancer risk. We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR = 0.78, 95% CI = 0.63-0.96, P = 0.021) compared with the wildtype homozygote (NN). The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.

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