ANTI-INFLAMMATORY, ANALGESIC AND ULCEROGENIC ACTIVITY OF VIGNA MUNGO LINN. LEAVES | Zendy

Md. Rageeb Md. Usman | Zendy; Shashikant D. Barhate | Zendy

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ANTI-INFLAMMATORY, ANALGESIC AND ULCEROGENIC ACTIVITY OF VIGNA MUNGO LINN. LEAVES

Author(s) -

Md. Rageeb Md. Usman,

Shashikant D. Barhate

Publication year - 2012

Publication title -

international journal of phytopharmacy

Language(s) - English

Resource type - Journals

ISSN - 2277-2928

DOI - 10.7439/ijpp.v1i2.206

Subject(s) - vigna , analgesic , anti inflammatory , traditional medicine , edema , chemistry , pharmacology , biology , medicine , botany

The anti-inflammatory, analgesic and ulcerogenic activity of extract of leaves of Vigna Mungo linn. (Leguminosae) were investigated as well as the mechanisms of action. The extract significantly (P<0.05) inhibited the formation of paw edema induced by Â Â Â carrageenan in rat and increased reaction latency to thermal pain in rat in a dose-dependent manner. The extract caused a significant (P<0.05) dose-dependent ulceration of rat gastric mucosa and concentration-dependent inhibition of hypotonicity-induced haemolysis of red blood cell. Also the extract significantly (P<0.05) inhibited the activates of the phospholipase A₂ and prostaglandine synthesis in a concentration related manner. These suggest that the leaves posses anti-inflammatory, analgesic and ulcerogenic activities mediated through sequential inhibition of the enzymes responsible for prostaglandine synthesis from arachidonic acid. Phytochemical analysis of the extract revealed the presence of glycoside, tannins, alkaloid, flavonoids and Saponins. Acute toxicity studies established an oral LD₅₀greater than 3000 mg/kg.

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