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Methanolic flowers extract of Nerium indicum was evaluated for hepatoprotective in rats. The plant extract (500 and 1000 mg/kg, p.o.) showed a remarkable hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in liver tissues. Carbon tetrachloride induced a significant rise in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT) and alkaline phosphatase (ALP). Treatment of rats with different doses of plant extract (500 and 1000 mg/kg) significantly (P<0.001) altered serum marker enzymes levels to against carbon tetrachloride treated rats. The activity of the extract at dose of 300 mg/kg was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective properties of Nerium indicum against carbon tetrachloride induced hepatotoxicity in rats.

PROTECTIVE EFFECT OF NERIUM INDICUM ON CCl4 INDUCED HEPATOTOXICITY IN RATS