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A high performance Liquid chromatographic method for quantification of trandolapril using UV detection was developed and validated. Trandolapril samples were analysed on Merck LiChroCART -RP C18 column (250x4.0, i.d.5 µm) and the mobile phase composition used for detection was combination of acetonitrile: methanol: phosphate buffer (0.025mM) pH3.0 (40:35:25)at a flow rate of 1 ml/min. The λmax used was 220nm with UV detection. The retention time of trandolapril by proposed method was found to be 2.750 ± 0.008 min. Peak area obtained were linearly related to concentration of drug in samples in range of 2.5-17.5 µg/mL having correlation coefficient of 0.999. The LOD and LOQ of trandolapril by proposed method was found to be 0.099 µg/mL and 0.300834 µg/ml respectively. The method was validated as per ICH guidelines for various parameters. The results for accuracy, precision and robustness were found to be within accepted limits.

A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR QUANTIFICATION OF TRANDOLAPRIL USING UV SPECTROMETRIC DETECTION