REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ARTESUNATE IN TABLET DOSAGE FORM | Zendy

Subhash Kale | Zendy; Mahesh Palled | Zendy; A. R. Bhat | Zendy; Mayura Kale | Zendy; Ritesh Bathe | Zendy

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REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ARTESUNATE IN TABLET DOSAGE FORM

Author(s) -

Subhash Kale,

Mahesh Palled,

A. R. Bhat,

Mayura Kale,

Ritesh Bathe

Publication year - 2011

Publication title -

international journal of biomedical and advance research

Language(s) - English

Resource type - Journals

eISSN - 2455-0558

pISSN - 2229-3809

DOI - 10.7439/ijbar.v2i3.27

Subject(s) - artesunate , chromatography , dosage form , acetonitrile , high performance liquid chromatography , artemisinin , methanol , materials science , chemistry , plasmodium falciparum , medicine , organic chemistry , malaria , immunology

Artesunate is a new potent antimalarial drug and is a synthetic analogue of artemisinin. A simple, economical, fast, and precise reverse phase high performance liquid chromatographic method has been developed for the determination of Artesunate in tablet dosage form. The present method was developed on C-18 Hypersil (5 micron 25 cmÃ— 4.6 mm) column, in isocratic mode with mobile phase acetonitrile: methanol (70: 30 v/v) at a constant flow rate of 1.0 ml/min and the detection wavelength was 211 nm. Proposed method was validated for precision, accuracy, linearity range, recovery, robustness and ruggedness. The developed method can be used for assay of Artesunate in pharmaceutical preparations

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