Open AccessVALIDATED UV SPECTROSCOPIC METHOD FOR ESTIMATION OF ZOLMITRIPTAN FROM TABLET FORMULATIONS
Author(s) -
N. G. Raghavendra Rao,
Syeda Humaira,
Mangesh R. Munde
Publication year - 2011
Publication title -
international journal of biomedical and advance research
Language(s) - English
Resource type - Journals
eISSN - 2455-0558
pISSN - 2229-3809
DOI - 10.7439/ijbar.v1i3.5
Subject(s) - zolmitriptan , dosage form , materials science , chromatography , biomedical engineering , mathematics , chemistry , medicine , receptor , sumatriptan , agonist , biochemistry
A simple, economical, sensitive and specific UV spectrophotometric method was developed for the estimation of Zolmitriptan in bulk drug tablet dosage form. The optimum conditions for the analysis of the drug were established. The wavelength maxima (λmax) for zolmitriptan were found to be 226.5 nm. The linearity for this method was found to be in the range of 1-5µg/ml. The method showed high sensitivity with reproducibility in results. The lower limit of detection and the limit of quantification were found to be 4.234and 12.702 respectively. The calibration curve was drawn by plotting graph between absorbance and concentration. Coefficient of correlation was 0.99. The regression of the curve was Y = 0.1751x +0.0476. Precision of the method was found to be 1.625 ± 0.324 against the label claim of 2.5mg. The percentage recovery was found to be 98.66 – 99.50. The sample solution was stable up to 12 hours. The proposed method may be suitably applied for the analysis of Zolmitriptan in tablet pharmaceutical formulation for routine analysis
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