Open AccessEpidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancers in a Multiethnic Malaysian Patient Population
Author(s) -
Chong Kin Liam,
Alex HwongRuey Leow,
Soon-Hin How,
YongKek Pang,
KeongTiong Chua,
Boon-Khaw Lim,
Nai-Lang Lai,
Yeh-Chunn Kuan,
Jayalakshmi Pailoor,
Pathmanathan Rajadurai
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.1.321
Subject(s) - epidermal growth factor receptor , epidermal growth factor , lung cancer , lung , medicine , oncology , cancer research , population , mutation , receptor , biology , genetics , environmental health , gene
Mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in non- small cell lung cancer (NSCLC) are predictive of response to EGFR-targeted therapy in advanced stages of disease. This study aimed to determine the frequency of EGFR mutations in NSCLCs and to correlate their presence with clinical characteristics in multiethnic Malaysian patients.
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