CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers | Zendy

Shiv Kumar Giri | Zendy; Anita Yadav | Zendy; Anıl Kumar | Zendy; Kapil Dev | Zendy; Sachin Gulati | Zendy; Ranjan Gupta | Zendy; Neeraj Aggarwal | Zendy; Sanjeev K. Gautam | Zendy

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CYP1A1 Gene Polymorphisms: Modulator of Genetic Damage in Coal-Tar Workers

Author(s) -

Shiv Kumar Giri,

Anita Yadav,

Anıl Kumar,

Kapil Dev,

Sachin Gulati,

Ranjan Gupta,

Neeraj Aggarwal,

Sanjeev K. Gautam

Publication year - 2012

Publication title -

asian pacific journal of cancer prevention

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.512

H-Index - 75

eISSN - 2476-762X

pISSN - 1513-7368

DOI - 10.7314/apjcp.2012.13.7.3409

Subject(s) - micronucleus test , carcinogen , genetics , genotype , gene , biology , buccal swab , micronucleus , genetic predisposition , microbiology and biotechnology , medicine , toxicity

It is well known that polycyclic aromatic hydrocarbons (PAHs) such as benzo (a) pyrene have carcinogenic properties and may cause many types of cancers in human populations. Genetic susceptibility might be due to variation in genes encoding for carcinogen metabolizing enzymes, such as cytochrome P-450 (CYP450). Our study aimed to investigate the effect of genetic polymorphisms of CYP1A1 (m1 and m2) on genetic damage in 115 coal-tar workers exposed to PAHs in their work place.

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