Open Accessβ-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways
Author(s) -
Yunhong Zhan,
Jing Liu,
Xiujuan Qu,
Kezuo Hou,
Kefeng Wang,
Yunpeng Liu,
Bin Wu
Publication year - 2012
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2012.13.6.2739
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , autophagy , apoptosis , mapk/erk pathway , viability assay , cancer research , elemene , chemistry , cell growth , mtt assay , biology , signal transduction , microbiology and biotechnology , biochemistry
Renal-cell carcinoma (RCC) is resistant to almost all chemotherapeutics and radiation therapy. β-Elemene, a promising anticancer drug extracted from a traditional Chinese medicine, has been shown to be effective against various tumors. In the present study, anti-tumor effects on RCC cells and the involved mechanisms were investigated.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom