Open AccessGST polymorphisms and early-onset coronary artery disease in young South African Indians
Author(s) -
Alisa Phulukdaree,
Sajidah Khan,
Devapregasan Moodley,
Anil A. Chuturgoon
Publication year - 2012
Publication title -
south african medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 57
eISSN - 2078-5135
pISSN - 0256-9574
DOI - 10.7196/samj.5520
Subject(s) - gstp1 , medicine , odds ratio , coronary artery disease , genotype , gastroenterology , confidence interval , genetics , gene , biology
Glutathione S-transferases (GSTs) detoxify environmental agents which influence the onset and progression of disease. Dysfunctional detoxification enzymes are responsible for prolonged exposure to reactive molecules and can contribute to endothelial damage, an underlying factor in coronary artery disease (CAD).
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