The relationship between trough concentration of vancomycin and effect on methicillin-resistant Staphylococcus aureus in critically ill patients | Zendy

Jamie Cheong | Zendy; Mohd MakmorBakry | Zendy; Chee Lan Lau | Zendy; Raha Abdul Rahman | Zendy

Open Access

The relationship between trough concentration of vancomycin and effect on methicillin-resistant Staphylococcus aureus in critically ill patients

Author(s) -

Jamie Cheong,

Mohd MakmorBakry,

Chee Lan Lau,

Raha Abdul Rahman

Publication year - 2012

Publication title -

south african medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.527

H-Index - 57

eISSN - 2078-5135

pISSN - 0256-9574

DOI - 10.7196/samj.5343

Subject(s) - medicine , critically ill , staphylococcus aureus , vancomycin , methicillin resistant staphylococcus aureus , intensive care medicine , trough (economics) , microbiology and biotechnology , bacteria , genetics , macroeconomics , economics , biology

The incidence of methicillin-resistant Staphylococcus aureus (MRSA) infections in intensive care units in Malaysia is significant. Invasive MRSA infections are commonly treated with vancomycin. In clinical practice, the serum vancomycin trough concentration is used as a surrogate marker of vancomycin efficacy. A low concentration of vancomycin may result in less effective therapy and increase the risk of bacterial resistance. We evaluated the relationship between the resolution of MRSA infections and trough concentrations of vancomycin.

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