Spontaneous Coronary Artery Dissection in a female patient with fragile X syndrome

Spontaneous coronary artery dissection (SCAD) is a rare but significant cause of acute coronary syndrome and sudden cardiac death. The first angiographic report of SCAD was done by Ciraulo in 1978. SCAD may present with a variety of symptoms, such as acute myocardial infarction, ventricular arrhythmiaa, and sudden cardiac death, or may also be asymptomatic. SCAD is most often diagnosed using coronary angiography. The pathogenesis of SCAD is unclear, but female gender, the peripartum period, and atherosclerosis are known to increase the risk of developing the condition. Genetic disease which involve connective tissue such as Marfan syndrome, Ehlers-Danlos syndrome and autoimmune disease such as systemic lupus erythematosus also known to be increased risk of SCAD. However, the relevance of the fragile X syndrome (FXS) has not yet been reported. Here, we report the case of a woman with SCAD and FXS.