Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities. | Zendy

Hirofumi Nakano | Zendy; Yuzuru Matsuda | Zendy; Kunio Ito | Zendy; SHUJI OHKUBO | Zendy; Makoto Morimoto | Zendy; Fusao Tomita | Zendy

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Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.

Author(s) -

Hirofumi Nakano,

Yuzuru Matsuda,

Kunio Ito,

SHUJI OHKUBO,

Makoto Morimoto,

Fusao Tomita

Publication year - 1981

Publication title -

the journal of antibiotics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.56

H-Index - 80

eISSN - 1881-1469

pISSN - 0021-8820

DOI - 10.7164/antibiotics.34.266

Subject(s) - antibiotics , fermentation , streptomyces , bacteria , biology , isolation (microbiology) , microbiology and biotechnology , streptomycetaceae , ethyl acetate , antimicrobial , actinomycetales , chemistry , biochemistry , genetics

Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The antibiotics are active against Gram-positive bacteria and experimental tumors such as mouse sarcoma 180 and mouse leukemia P388.

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