Open AccessGilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.
Author(s) -
Hirofumi Nakano,
Yuzuru Matsuda,
Kunio Ito,
Shuji Ohkubo,
Makoto Morimoto,
Fusao Tomita
Publication year - 1981
Publication title -
journal of antibiotics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.56
H-Index - 80
eISSN - 1881-1469
pISSN - 0021-8820
DOI - 10.7164/antibiotics.34.266
Subject(s) - antibiotics , fermentation , streptomyces , bacteria , biology , isolation (microbiology) , microbiology and biotechnology , streptomycetaceae , ethyl acetate , antimicrobial , actinomycetales , chemistry , biochemistry , genetics
Gilvocarcin V and gilvocarcin M, a group of antitumor antibiotics with a novel skeleton, were discovered in culture broths of Actinomycete DO-38. The producing organism, subsequently determined to be a new species and named Streptomyces gilvotanareus (NRRL 11382). Gilvocarcin V and M were isolated by ethyl acetate extraction and chromatography on silica gel. The antibiotics are active against Gram-positive bacteria and experimental tumors such as mouse sarcoma 180 and mouse leukemia P388.