Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.
Author(s) -
Xiaodong Feng,
Katherine L. Tucker,
Laurence D. Parnell,
Jian Shen,
YuChi Lee,
José M. Ordovás,
Wenhua Liu,
ChaoQiang Lai
Publication year - 2013
Publication title -
pubmed
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.499
H-Index - 78
ISSN - 0964-7058
DOI - 10.6133/apjcn.2013.22.1.09
Subject(s) - type 2 diabetes , medicine , diabetes mellitus , insulin resistance , single nucleotide polymorphism , irs1 , minor allele frequency , haplotype , endocrinology , population , allele , biology , genetics , genotype , insulin receptor , gene , environmental health
Published data concerning associations between IRS1 variants and type 2 diabetes and related traits have been inconsistent. We examined the relationship between common variants in IRS1, type 2 diabetes, and related traits including insulin resistance, hyperglycemia and DNA damage in the Boston Puerto Rican Health Study.
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