Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. | Zendy

Malek Zarei | Zendy; Masoumeh Sabetkasaei | Zendy; Taraneh Moini Zanjani | Zendy

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Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain.

Author(s) -

Malek Zarei,

Masoumeh Sabetkasaei,

Taraneh Moini Zanjani

Publication year - 2014

Publication title -

pubmed

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.519

H-Index - 31

ISSN - 2008-823X

DOI - 10.6091/ibj.1282.2013

Subject(s) - neuropathic pain , medicine , anesthesia , paroxetine , allodynia , hyperalgesia , sciatic nerve , nerve injury , nociception , sciatic nerve injury , pharmacology , receptor , serotonin

P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could attenuate allodynia and hyperalgesia in chronic constriction injury (CCI) model of neuropathic pain when used preemptively or after the sciatic nerve injury.

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