Clinical Pharmacology in Old Persons | Zendy

Paul A.F. Jansen | Zendy; J. R. B. J. Brouwers | Zendy

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Clinical Pharmacology in Old Persons

Author(s) -

Paul A.F. Jansen,

J. R. B. J. Brouwers

Publication year - 2012

Publication title -

scientifica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.474

H-Index - 21

ISSN - 2090-908X

DOI - 10.6064/2012/723678

Subject(s) - pharmacotherapy , medicine , pharmacodynamics , clinical pharmacology , epidemiology , polypharmacy , pharmacology , intensive care medicine , drug , public health , multimorbidity , geriatrics , pharmacokinetics , psychiatry , pathology , chronic disease

The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities and are treated with a large number of medicines. In advanced age, the pharmacokinetics and pharmacodynamics of many drugs are altered. In addition, pharmacotherapy may be complicated by difficulties with obtaining drugs or adherence and persistence with drug regimens. Safe and effective pharmacotherapy remains one of the greatest challenges in geriatric medicine. In this paper, the main principles of geriatric pharmacology are presented.

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