In vitro and in vivo characteristics of fluorapatite-forming calcium phosphate cements | Zendy

S. Takagi | Zendy; Stan Frukhtbeyn | Zendy; L.C. Chow | Zendy; Akiyoshi Sugawara | Zendy; K. Fujikawa | Zendy; Hidehiro Ogata | Zendy; Makoto Hayashi | Zendy; Binnai Ogiso | Zendy

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In vitro and in vivo characteristics of fluorapatite-forming calcium phosphate cements

Author(s) -

S. Takagi,

Stan Frukhtbeyn,

L.C. Chow,

Akiyoshi Sugawara,

K. Fujikawa,

Hidehiro Ogata,

Makoto Hayashi,

Binnai Ogiso

Publication year - 2010

Publication title -

journal of research of the national institute of standards and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.202

H-Index - 59

eISSN - 2165-7254

pISSN - 1044-677X

DOI - 10.6028/jres.115.020

Subject(s) - fluorapatite , in vivo , calcium , phosphate , materials science , in vitro , mineralogy , chemistry , nuclear chemistry , apatite , metallurgy , biochemistry , biology , microbiology and biotechnology

This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

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