Open AccessHair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin‐Derived Precursors
Author(s) -
Wang Xiaoxiao,
Wang Xusheng,
Liu Jianjun,
Cai Ting,
Guo Ling,
Wang Shujuan,
Wang Jinmei,
Cao Yanpei,
Ge Jianfeng,
Jiang Yuyang,
Tredget Edward E.,
Cao Mengjun,
Wu Yaojiong
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0397
Subject(s) - hair follicle , stem cell , biology , regeneration (biology) , microbiology and biotechnology , skin repair , sebaceous gland , dermal papillae , epidermis (zoology) , progenitor cell , pathology , wound healing , immunology , endocrinology , anatomy , medicine
A combination of cultured epidermal stem cells (Epi‐SCs) derived from the epidermis and skin‐derived precursors (SKPs) was capable of reconstituting functional hair follicles and sebaceous glands (SG). The results indicate that cultured Epi‐SCs and SKPs are sufficient to generate de novo hair follicles and SGs, implying great potential to develop novel bioengineered skin substitutes with appendage genesis capacity.