Open AccessStem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts
Author(s) -
Pomeroy Jordan E.,
Hough Shelley R.,
Davidson Kathryn C.,
Quaas Alex M.,
Rees Jordan A.,
Pera Martin F.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0250
Subject(s) - reprogramming , microbiology and biotechnology , stem cell , biology , induced pluripotent stem cell , cell , genetics , embryonic stem cell , gene
The current understanding of the induction of pluripotency by defined factors indicates that the process occurs in discrete stages characterized by specific alterations in the cellular transcriptome and epigenome. In this study, tools were generated to characterize the transition to a fully reprogramed state. The findings could facilitate studies of the final stages of reprogramming of human cells to pluripotency and provide a simple means for prospective identification of fully reprogrammed cells.