Open AccessChondroitin Sulfate Immobilized on a Biomimetic Scaffold Modulates Inflammation While Driving Chondrogenesis
Author(s) -
Corradetti Bruna,
Taraballi Francesca,
Minardi Silvia,
Van Eps Jeffrey,
Cabrera Fernando,
Francis Lewis W.,
Gazze Salvatore A.,
Ferrari Mauro,
Weiner Bradley K.,
Tasciotti Ennio
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0233
Subject(s) - chondrogenesis , mesenchymal stem cell , microbiology and biotechnology , stem cell , proinflammatory cytokine , extracellular matrix , cartilage , tissue engineering , population , chemistry , inflammation , immunology , medicine , biology , biomedical engineering , anatomy , environmental health
This article proposes a chondroitin sulfate‐based biomimetic scaffold that recapitulates the physicochemical features of the chondrogenic niche and retains the immunosuppressive potential of mesenchymal stem cells in vitro, either in response to a proinflammatory cytokine or in the presence of stimulated peripheral blood mononuclear cells.