Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age‐Related Osteoporosis | Zendy

Kiernan Jeffrey | Zendy; Hu Sally | Zendy; Grynpas Marc D. | Zendy; Davies John E. | Zendy; Stanford William L. | Zendy

Open Access

Systemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age‐Related Osteoporosis

Author(s) -

Kiernan Jeffrey,

Hu Sally,

Grynpas Marc D.,

Davies John E.,

Stanford William L.

Publication year - 2016

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2015-0231

Subject(s) - mesenchymal stem cell , osteoporosis , medicine , transplantation , stromal cell , bone remodeling , progenitor cell , stem cell , pathology , biology , microbiology and biotechnology

The injection of minimally expanded exogenous mesenchymal stromal cells (MSCs) into a mouse model of human age‐related osteoporosis led to long‐term engraftment and markedly increased bone formation. This led to improved bone quality and turnover and sustained microarchitectural competence, establishing proof of concept that MSC transplantation may be used to prevent or treat human age‐related osteoporosis.

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