Open AccessSystemic Mesenchymal Stromal Cell Transplantation Prevents Functional Bone Loss in a Mouse Model of Age‐Related Osteoporosis
Author(s) -
Kiernan Jeffrey,
Hu Sally,
Grynpas Marc D.,
Davies John E.,
Stanford William L.
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0231
Subject(s) - mesenchymal stem cell , osteoporosis , medicine , transplantation , bone remodeling , stromal cell , progenitor cell , stem cell , pathology , cancer research , biology , microbiology and biotechnology
The injection of minimally expanded exogenous mesenchymal stromal cells (MSCs) into a mouse model of human age‐related osteoporosis led to long‐term engraftment and markedly increased bone formation. This led to improved bone quality and turnover and sustained microarchitectural competence, establishing proof of concept that MSC transplantation may be used to prevent or treat human age‐related osteoporosis.